Abdominal CT scan showed no signs of intra or retroperitoneal abscess; the retroperitoneal Selleckchem Gefitinib hematoma appeared decreased in size. No evidence of chest or urinary tract infections was demonstrated. Eventually, magnetic resonance imaging (MRI) showed osteomyelitis at III and IV lumbar vertebrae with bone erosion and inflammation of disc

space; a small collection in the paraRepotrectinib solubility dmso vertebral tissue at that level was also detected (Figure 3). No vertebral fractures or spinal involvement were demonstrated and clinical assessment was performed to confirm spinal stability. Given the results of cultures on peritoneal fluid collected at time of laparotomy, that showed polimicrobial contamination by Escherichia coli, Enterobacter cloacae, Candida albicans and Candida krusei, treatment was started with intravenous piperacillin/tazobactam and fluconazole. Ten sessions of hyperbaric oxygen therapy (HBOT)

were administered in addition. Analgesia and bed rest were effective in alleviating symptoms. Clinical response to therapy was satisfactory and CRP levels were decreased after 2 weeks of treatment. Repeated sets of blood cultures were negative. The patient was discharged in 20 days on oral Selleckchem AR-13324 medications (ciprofloxacin, thrimethoprim and fluconazole) for 6 weeks and prescription for a back brace and physiotherapy. Clinical improvement was confirmed at 10 days follow-up. He made a full recovery in 2 months. Figure 3 Diagnostic MRI. Contrast MRI demonstrated a small paravertebral collection (a) and osteomyelitis at L III – L IV with areas of bone erosion (b) (T1 weighted images are shown). Discussion Pyogenic vertebral osteomyelitis is a rare disease that counts for 2-5% of all cases of osteomyelitis, with an annual incidence of 0.4 to 2.4/100′000

among European population [2]. Predisposing factors 3-oxoacyl-(acyl-carrier-protein) reductase are intravenous drug use, immunosuppression, chronic illnesses and insulin-dependent diabetes mellitus. Typically, vertebral osteomyelitis is a complication of bacterial endocarditis and septicemia. Direct contamination associated with spinal surgery or epidural procedures appears to be of increasing importance among possible etiologies [1, 2]. According to observational studies, Staphylococcus aureus (20-84%) and Enterobactericeae (33%) are the most common pathogens, with anaerobes (3%) and fungi (1-2%) rarely involved; less than 10% are polimicrobial infections [11]. In trauma setting, direct or trans-abdominal penetrating injuries to the spine are at risk of developing secondary infections, particularly when a hollow viscus is perforated [3, 10]. In the presented case, a pointed metal stick caused a perforation of the transverse colon and a retroperitoneal injury. Bone infection was considered to be secondary to direct contamination from the peritoneum and treated accordingly. Diagnosis of pyogenic vertebral osteomyelitis is usually guided by clinical suspicion in the presence of persistent back pain and remitting fever.