Amlodipine/valsartan at week 8 lowered MSSBP last observation carried forward significantly>A (33.3 vs 26.6 mm Hg, P<0.0001). Lowering of MSSBP with A/V significantly exceeded that of A in several specified subgroups-the selleck chemicals llc elderly (>= 65 years), isolated systolic hypertension, and those with body mass index (BMI) >= 30 kg/m(2). More patients

treated with A/V than A achieved BP control (<140/90 mm Hg) both at weeks 8 (49.8 vs 30.2%; P<0.0001) and 12 (57.2 vs 35.9%; P<0.0001). Both treatment regimens were well tolerated. In conclusion, the strategy of initiating combination antihypertensive drug therapy in blacks with stage 2 hypertension with amlodipine/valsartan achieves greater and quicker reductions in BP as well as significantly higher BP control rates than starting treatment with amlodipine monotherapy. Journal of Human Hypertension (2009) 23, 479-489; doi:10.1038/jhh.2008.153; published online 29 January 2009″
“We have studied the time-scale and temperature dependence of the magnetization reversal in perpendicular magnetic recording media. One of the under-reported phenomena associated with this reversal is the thermal dependence of the squareness of www.selleckchem.com/products/ABT-263.html the magnetic hysteresis loop. Understanding this phenomenon is important because the coercive squareness parameter S* is often used to evaluate the strength of the magnetic exchange-coupling interactions between the grains. In this work, we demonstrate

that DMXAA chemical structure S* is a dynamic quantity which depends on the thermal agitation of the magnetization, and it is imperative to take this dependence into account in interpreting magnetic and microstructural effects. Based on the Sharrock model for the dynamic coercivity,

we built an expression for the time-scale and temperature dependence of S* in highly oriented perpendicular magnetic recording media. Fits of experimental data to the resulting expression were then used to extract the intrinsic squareness parameter S(int)(*) which originates in the thermal-independent demagnetization and exchange-interaction effects. S(int)(*) was estimated for two sets of perpendicular recording media samples. For the first set of media samples showing progressively smaller grain sizes, the values of S* measured at the normal magnetometry time-scales of milliseconds to seconds indicated progressively smaller values. In contrast, the values of the thermal-independent S(int)(*) determined from applying the above model were progressively larger. This discrepancy can only be explained on the basis of progressively stronger intergranular exchange coupling, which is offset by strong thermal effects at small grain sizes. For the second set of media samples with increasingly larger segregant oxide content, progressively smaller values of both S* and thermal-independent S(int)* were observed, thus verifying the strong intergranular segregation effects due to greater nonmagnetic grain boundary phase.