At this time, the Azathioprine was ceased due to nausea and poor oral intake. Approximately 8 weeks after the first admission and while still immunosupressed for presumptive treatment for Crohn’s Disease, the patient presented Selisistat concentration with night sweats, marked weight loss, lethargy and hypoxia. Sputum and blood cultures collected at this time grew

Mycobacterium Tuberculosis. Quantiferon gold was indeterminate and HIV testing was negative. All immunosupression was ceased and directly observed therapy commenced for miliary tuberculosis infection with the presumptive diagnosis for the necrotizing granuloma in the ascending colon thought to be gastrointestinal tuberculosis. K LIEW, G RADFORD-SMITH Gastroenterology Department, Royal

Brisbane and Women’s Hospital, Brisbane, Australia see more Background: Human leukocyte antigen B27 (HLA B27) is involved in antigen presentation to T cells. It has been associated with rheumatological manifestations of inflammatory bowel disease (IBD). Recognized limitations of studies investigating HLA associations include statistical power, and the majority of HLA association studies in IBD have involved fewer than 100 cases. The prevalence of HLA B27 has also been noted to vary between studies, and its prevalence in different ethnic groups differs. Objective: Our aims are to establish the prevalence of HLA B27 in a large, consecutive series of patients with Crohn’s disease at a major secondary and tertiary center in Australia, and to compare the natural history of inflammatory bowel disease in patients with HLA B27 and those without. Of interest are whether there are differences in location and severity of Crohn’s disease, and

whether differences in extraintestinal manifestations exist. This will identify if HLA B27 is a useful prognostic marker and assist in planning treatment for patients with Crohn’s disease. Method: We retrospectively reviewed medical data of 476 hospital patients with Crohn’s disease who had been referred for HLA B27 typing between September 1999 and August 2013 from the IBD service at the Royal Brisbane Hospital. Data were reviewed from the Prime IBD Database, including gender, age at diagnosis, location, disease behaviour and the presence of extraintestinal 上海皓元 manifestations. Patient charts were reviewed for further clinical information if they were available. Results: The database included 476 patients with a HLA B7 result. 19 (4%) were HLA B27 positive. In this cohort, 62% of participants were female, consistent with published reports of greater prevalence of Crohn’s disease in adult females. The median age at diagnosis is 26 for HLA B27 positive patients and 28 for HLA B27 negative patients. Differences in location and behaviour of Crohn’s disease did not reach statistical significance. In HLA B27 positive patients isolated ileal disease occurred in 37% of cases where results were available, as compared to 48% in HLA B27 negative patients (p = 0.2461).