“
“Dexrazoxane (ICRF-187) has been clinically used to reduce doxorubicin-induced cardiotoxicity for more than 20 years. It has been proposed that dexrazoxane may act through its rings-opened hydrolysis product ADR-925, which can either remove iron from the iron-doxorubicin complex or bind to free iron, thus preventing iron-based oxygen radical formation. However, it is not known whether the antioxidant actions of dexrazoxane are totally dependent on its metabolization to its rings-opened hydrolysis product and whether dexrazoxane has any effect on the iron-independent oxygen free radical production. In this study,

we examined the scavenging effect of dexrazoxane on hydroxyl, superoxide, lipid, DPPH and ABTS(+) free radicals in vitro solution www.selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html systems. The results demonstrated that dexrazoxane was an antioxidant that could effectively scavenge these free radicals and the scavenging effects of dexrazoxane did not require the Selleck FDA approved Drug Library enzymatic hydrolysis. In addition, dexrazoxane was capable to inhibit the generation superoxide and hydroxyl radicals in iron free reaction system, indicating that the antioxidant properties of dexrazoxane were not solely dependent on iron chelation. Thus the application of dexrazoxane should not be limited

to doxorubicin-induced cardiotoxicity. Instead, as an effective antioxidant that has been clinically proven safe, dexrazoxane may be used in a broader spectrum of diseases that are known to be benefited by antioxidant treatments.”
“Bubble-electrospinning

is suggested to produce micro/nano fibers. Contrary to classical electro-spinning where a high voltage is applied to overcome the surface tension of the Taylor’s cone, in bubble-electrospinning, the voltage is applied to overcome the bubble’s surface tension, which mainly depends upon the size of the bubble. Instead of single jet, millions of charged jets are observed simultaneously. In this article, we design a single bubble-electrospinning to primarily study the effect of concentration on the spinning procedure. Polyvinylpyrrolidone (PVP) is used in the experiment. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 1161-1165, 2011″
“The occurrence of non-Hodgkin’s AZD7762 datasheet lymphoma in systemic sclerosis is an uncommon event. In our scleroderma cohort, a case of primary gastric B-cell lymphoma was diagnosed in 2007. The patient was a 45-year-old woman suffering from late systemic sclerosis sine scleroderma in whom non-Hodgkin’s lymphoma presented with progressive weight loss, later with gastrointestinal symptoms. Subsequently, we retrospectively analyzed the charts of 251 systemic sclerosis patients consecutively admitted to our Unit from 2000 to 2008 to search for other non-Hodgkin’s lymphoma cases (prevalence, 0.49%). Then we performed a Pubmed search for “”systemic sclerosis & non-Hodgkin’s lymphoma,”" limited to the English language.