The emission spectra of the Fe3O4@Y2O3:Tb3+ composite particles consisted of three easily distinguishable f-f transitions within the terbium ions. The strong green emission band with a maximum at 544 nm corresponds to the 5D4 → 7F5 transition. The blue emission at 480 to 510 nm is another characteristic of the 5D4 → 7F6 transition in Tb ions. The feeble yellow-near-red band in the range of 577 to 600 nm was assigned to the 5D4 → 7F4 transition. The characteristic emission and excitation peaks were similar to those observed in previous studies for

pure Y2O3:Tb3+ nanocrystals, which suggest that the luminescent properties are maintained in the final composite particles [21, 22]. Figure 5 PL excitation and emission spectra of Fe 3 O 4 @Y 2 O 3 :Tb 3+ composite particles. To examine the

magnetic GDC-0449 purchase properties of the bare Fe3O4 and core-shell Fe3O4@Y2O3:Tb3+ particles, the magnetization curves were measured by QD-VSM with a magnetic field cycle between −10 and +10 kOe at 300 K, as shown in Figure 6. The saturation magnetization value of the Fe3O4@Y2O3:Tb3+ particles was 15.12 emu/g. This value is much lower than that (34.97 emu/g) of the bare Fe3O4 due to diamagnetic Y2O3:Tb3+ thin shell coating. The coercivity at 300 K was negligible, indicating typical superparamagnetic behavior. Although thin shell coating reduces VEGFR inhibitor the magnetization of the bare Fe3O4 significantly, the Fe3O4@Y2O3:Tb3+ composites still showed strong magnetization, which suggests their suitability for magnetic pentoxifylline targeting and separation. The inset in Figure 6 shows that bifunctional Fe3O4@Y2O3:Tb3+ composites can be attracted easily by an external magnet and show strong eye-visible green luminescence upon the excitation of a commercially available SU5402 supplier 254-nm UV lamp. Therefore, bifunctional Fe3O4@Y2O3:Tb3+ composites exhibit good magnetic and optical properties and have

potential applications in targeting and bioseparation. Figure 6 Room temperature magnetization curves of bare Fe 3 O 4 and Fe 3 O 4 @Y 2 O 3 :Tb 3+ composite particles. Conclusions Bifunctional Fe3O4@Y2O3:Tb3+ composites were prepared using a facile urea-based homogeneous precipitation method. These composite particles offer two distinct functionalities: an inner Fe3O4 core, which gives the composites strong magnetic properties, making them easy to manipulate magnetically, and an outer Y2O3:Tb3+ shell with strong luminescent properties. A similar approach can be used to develop certain bifunctional composites with different core-shell structures. In addition, the simple design concept for bifunctional composites might open up new opportunities in bioanalytical and biomedical applications. Acknowledgements This work was supported by the National Research Foundation of Korea (grant no.