There was no proven correlation between Helicobacter spp. and colorectal cancer. However, in another review, Risch summarized and analyzed seven published studies (three case–control studies and four cohort studies) with regard to pancreatic cancer odds ratio (OR) for H. pylori positivity Selleckchem BGJ398 [58]. The author found that H. pylori colonization significantly increased the risk for pancreatic cancer, with a pooled OR for this combined analysis of 1.65 (95% CI: 1.30–2.09). In light of a published case–control study that showed increased risk of pancreatic cancer with non-O blood groups (A, B, and AB) compared to O [59]. Risch postulated that N-nitroso compounds

have blood-borne trophic effects on pancreatic ductular epithelium that act combined with H. pylori infection, embedded in the background of host genetic variations and ABO that may affect other aspects of inflammatory response, could lead to development of pancreatic cancer. Koshiol et al. [60] conducted the study of 350 lung adenocarcinoma cases, 350 squamous cell carcinoma cases, and 700 nested controls within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) cohort of male Finnish smokers. To test the associations between H. pylori seropositivity (ELISA) and lung cancer risk using conditional logistic Selleck Anti-infection Compound Library regression,

controls were one-to-one matched by age and date of baseline serum draw. The results of MCE this study did not found an association between H. pylori seropositivity and either adenocarcinoma (OR 1.1, 95% CI: 0.75–1.6) or squamous cell carcinoma (OR 1.1, 95% CI: 0.77–1.7), and the results were similar

for CagA- and CagA+ H. pylori seropositivity. Nevertheless, these results should be considered in regard to the relatively high H. pylori seropositivity in 79.7% of cases and in 78.5% of controls. Still, a possible association between H. pylori infection and lung cancer remains intriguing because lungs develop embryologically from the same endodermal cells that line the GI tract and contain cells that produce peptide hormones like gastrin, leaving open the possibility that trophic effects in conjunction with systemic effects of local inflammation (H. pylori lipopolysaccharide) may promote cellular proliferation in the lungs, as well. In conclusion, in the last year, several diseases have been investigated for a possible association with H. pylori infection. Considering the high number of papers published so far, we may easily state that this topic is still one of the most fascinating inside the H. pylori research area. Competing interests: the authors have no competing interests;][#,63]?> “
“Evidence has shown benefits of single-strain probiotics for Helicobacter pylori eradication. We investigated the effects of adding a multistrain probiotic compound on bismuth-containing quadruple therapy for H. pylori infection. Adult patients with peptic ulcer disease and confirmed H.