15 The average working hours per week for male workers of the car battery industry was more than 50 which possibly leads to the fatigue-related impact of long working hours and occupational dissatisfaction. However, a recent study on 96915 workers in the United States indicates that although males show greater risks of injury compared to females, working hours is significantly associated with toxic risk only for women. This is probably due to the decreased recovery time and inadequate sleep, and elevated fatigue-related impact of long working hours for female workers.17 Nevertheless, additional objective measures are warranted in order to come to a more reliable conclusion.
Chronic lead exposure Inhibitors,research,lifescience,medical is implicated in the development of hypertension.18 Although 23.2% of workers had higher than normal systolic or diastolic blood pressures, the diagnosis of hypertension could not be made in the first-time visit. Our findings showed no association between systolic/diastolic blood pressure and BLC, which was consistent with Inhibitors,research,lifescience,medical other reports.19,20 It seems that lead Inhibitors,research,lifescience,medical exposure was not sufficiently durable to cause hypertension in this young
population. In this study, the level of education was inversely correlated with BLC which was consistent with the reports from other developing countries.21-23 Thus, improvement of education and socioeconomic status plays key role in the prevention of lead poisoning in these countries. According to guidelines,14 workers with severe lead poisoning should be hospitalized and treated with parenteral infusion. Since no severe case of lead poisoning was found among the studied population, Inhibitors,research,lifescience,medical workers were asked to avoid lead exposure and/or treated as outpatients. Toxicokinetics With normal renal function, lead is
excreted in the urine. Random urine sample shows short-term exposure to heavy metals.24,25 Urine and blood lead correlations are not reliable enough to substitute urine lead concentration for BLC, especially when the exposure is mild and BLC is less than 100 µg/L.24,26 Gulson et al, believed that the inaccuracy in predicting BLC by measuring ULC mostly applies Inhibitors,research,lifescience,medical to children and female Quizartinib purchase adults because of the potential Vasopressin Receptor contamination during sampling.24 On the other hand, Moreira et al. claimed that spot urine test could be used to replace blood sampling for the evaluation of occupational lead exposure in both children and adults.27 Hematologic Manifestations Lead poisoning is a known cause of microcytic anemia.1 Although we failed to detect depressed Hb/Hct concentrations in workers, Mean Corpuscular Hemoglobin (MCH) and Mean Corposcular Hemoglobin Concentration (MCHC) values were negatively correlated with blood lead concentration. Other RBC indices were not significantly affected. Katavolos et al. demonstrated that MCHC and hemoglobin concentration in two avian species decreased significantly with rising blood lead concentration.