55; 95% CI 1.11-2.17; P = 0.01) was more frequent in patients with HCC than the CC or CT variants, but the frequency of the CC genotype was not significantly different between HCC and healthy donors (P = 0.249); at rs3761549, the CC genotype (OR 1.92; 95% CI 1.39-2.64; P < 0.001) was more frequent in patients find more with HCC than the TT or CT variants, but the frequency of the TT genotype was not significantly different between HCC and healthy donors (P = 0.118). Compared to HCC patients, the CT genotype at both rs2280883 and Selleck DMXAA rs3761549 was significantly more frequent in healthy donors than the CC or TT variants (both P < 0.001) (Table 3 and Additional file 1: Table S1). For CHB donors and healthy donors, the CT genotype at rs2280883 was
more frequent in healthy donors than the CC or TT variants (P = 0.004), but there were no significant differences in the distribution of either CC or TT genotypes between CHB donors and healthy donors (P = 0.051, P = 0.479); at rs3761549, the CC genotype (OR 1.63; 95% CI 1.18-2.25; P = 0.003) was more frequent in patients with CHB than the TT or CT variants, but there was no significant difference in the distribution of the TT genotype between CHB donors and healthy donors (P = 0.198). The selleck products CT genotype was more frequent in healthy donors than the CC and TT variants (P < 0.001) (Table 3 and Additional file 1: Table S1). However, there were no significant
differences in the FOXP3 Carnitine palmitoyltransferase II genotype distribution between HCC donors and CHB donors at either rs2280883 or rs3761549 (Table 3 and Additional file 1: Table S1). Compared to healthy donors, the TT genotype at rs2280883 was more frequent in patients with HCC, but this genotype frequency was not significantly different between CHB and healthy donors, in addition, the CC
genotype at rs2280883 was more frequent in CHB patients (16.0%) than in HCC patients (13.8%), but the TT genotype was more frequent in HCC patients (79.6%) than in CHB patients (74.1%); these results showed that the TT genotype at rs2280883 was associated with HCC but not with CHB. The stratified analysis of the association between FOXP3 genotypes and HCC clinical pathology variables Because the FOXP3 genetic variants rs2280883 and rs3761549 were significantly associated with susceptibility to HCC, further analysis was performed to determine the relationship between the FOXP3 genotype and multiple HCC clinical pathology variables, such as age, gender, alcohol abuse history, tumor size, tumor nodule, tumor grade, lymph node metastasis, portal vein tumor thrombus, distant metastasis and recurrence. Follow-up records had not been completed for all of the patients, and detailed clinical pathology variables were available for only 188 cases; these details are shown in Table 4. The CC genotype of rs3761549 was more frequent in HCC patients with portal vein tumor thrombus (P = 0.02), and the TT and CT genotypes were more common in patients with recurrent HCC (P = 0.001).