familiarity-based recognition). In this article, a new signal-detection model is proposed that does not deny either the validity of dual-process theory or the possibility that remember/know judgments can when used in the right way help to distinguish between memories that are largely recollection based from those

that are largely familiarity based. It does, however, agree with all prior signal-detection-based critiques of the remember/know procedure, which hold that, as it is ordinarily used, the procedure mainly distinguishes strong memories from weak memories (not recollection FAK inhibitor from familiarity).”
“It is widely assumed that older adults

suffer a deficit in the psychological processes that underlie remembering of contextual or source information. This conclusion is based in large part on empirical interactions, including disordinal ones, that reveal differential effects of manipulations of memory strength on recognition in young and old subjects. This article lays out an alternative theory that takes as a starting point the overwhelming evidence from the psychometric literature that the effects of age on memory share a single mediating influence. ARS-1620 mouse Thus, the theory assumes no differences between younger and older subjects other than a global difference in memory fidelity that is, the older subjects are presumed to have less valid representations Ceritinib clinical trial of events and objects than are young subjects. The theory is articulated through 3 major assumptions and implemented in a computational model. DRYAD,

to simulate fundamental results in the literature on aging and recognition, including the very interactions taken to imply selective impairment in older people. The theoretical perspective presented here allows for a critical examination of the widely held belief that aging entails the selective disruption of particular memory processes.”
“To the Editor: The letter by Asrani et al. (May 2 issue)(1) reports cases of hepatocellular carcinoma in patients who have undergone Fontan palliation for univentricular hearts. Our practice includes yearly screening for adult patients who have undergone Fontan palliation, including imaging and testing of the alpha-fetoprotein level. We report on a 51-year-old man with a univentricular heart (double-inlet left ventricle) who underwent a classic atriopulmonary Fontan procedure in 1982. Progressive dyspnea, atrial arrhythmias, ascites, and pleural effusions developed in the context of normal ventricular systolic function. Evaluation of the liver, including biopsy and magnetic resonance imaging (MRI), showed congestive …