Future researches

should elucidate the specific context that is responsible for specific functions of miR-210. In addition, how to integrate multiple functionally Bindarit molecular weight different but related targets of one peculiar miRNA such as miR-210, so as to precisely predict its functions remains a great challenge. Besides functions of miR-210, we also reviewed the diagnostic and prognostic value of it. As described above, up-regulated miR-210 is not only be detected in cancer tissues, but also in body fluids. It is feasible to discriminate cancer from non-cancer with a specific group of miRNAs including miR-210. However, when it comes to prognosis, it is far Volasertib chemical structure too early to use miR-210 alone as a prognostic factor without dispute, and more investigations are needed to elucidate the underlying mechanism of such discrepancy. In future, global analysis of large cohorts of patients with not

only miRNAs expression profile but also mRNAs expression profile, even integrated with other genetic information such as DNA copy number variance, single nucleotide polymorphisms, will provide us more insights about significant prognostic find more factors as well as novel therapeutic targets. Acknowledgements This study was supported by National Natural Science Foundation of China (Grant no. 81272501). We acknowledge Dr. David L, Roerig for critical reading of the manuscript. References 1. Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell 2009,136(2):215–233.PubMedCentralPubMed 2. Krol J, Loedige I, Filipowicz W: The widespread regulation of microRNA biogenesis, function and decay. Nat Rev

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