MIR was studied in 21 patients with episodic TTH and 30 healthy subjects, with age and sex matched to the study cohort. Median age of patients was 17.0 years (ranged
16-49 years), median duration of disease 12 months (1-5 years), and median frequency of headache 7.5 d per month.
The second period of suppression (S2) of MIR was reduced in intensity and duration in 10% of controls and 66.7% (confidence interval (CI)=45.3%-85%; P < 0.05) of patients with episodic TTH (chi 2=74.9; P < 0.001). In 3 (14.3%) of patients with episodic TTH, S2 was completely absent. No find more significant correlation between the duration of disease and headache frequency was found.
Our results confirm the link between episodic TTH and reduction or absence of S2. Teenage patients with episodic TTH may exhibit marked pathological changes in S2 in contrast to older individuals.”
“The effects of aqueous
leaf extract of Bryophyllum pinnatum on the blood pressure of anaesthetized cats, as well as on the liver and kidney status of the rabbit were investigated in this study. The results revealed that, the extract produced a small fall in the blood pressure of the anaesthetized cat and also reduced the effect of adrenaline-induced elevation of blood pressure. In rabbits, biochemical analysis of serum was carried out; urea and creatinine were used as tests of its effect on the renal function while alkaline phosphatase (ALP), aspartate Savolitinib transaminase (AST) and alanine transaminase (ALT) served as enzyme SRT2104 indices of the liver function. In addition, the tissues of the liver and kidney were microscopically examined. The treated rabbits showed a significant decrease (P < 0.05) in their serum creatinine accompanied by significant increase in their serum urea (P < 0.05). No significant
changes of these biochemical parameters were seen in the serum of control animals. While a significant increase (P < 0.05) was observed in the activity of the ALP of the treated animals, a non-significant increase (P > 0.05) was recorded in the AST and ALT aminotransferases of both the treated and control animals. The increase recorded in the treated group was much higher (8.64 and 13.63%) as compared to the control group (0.69 and 7.05%). The histopathological examination of the kidney and liver of treated animals showed shrunken glomeruli with increased urinary space, mild necrosis of the tubules and hyaline droplets, while the liver tissue revealed necrosis of the liver cells, lymphocytic infiltration and peri-cuffing of the bile duct. The control animals, however, showed normal histological structure. In addition after 4 weeks of treatment, body weight in the control group was significantly higher than those in the treated group. It was concluded that the pharmacological basis for the use of B. pinnatum among the Igbos of Nigeria to lower blood pressure was established by this study.