Our results

are instead consistent with a role for beta oscillations in “sensorimotor integration” (Baker, 2007 and Lalo et al., 2007). Similar results have been reported in the STN of parkinsonian humans (Williams et al., 2003), where an instruction cue resulted in a beta ERS only if it was informative about the direction of a subsequent required movement. By contrast, the strong ERD seen after the ERS on Immediate-GO trials appeared more directly linked to motor performance. The ERD was present Doxorubicin mw as rats performed the left/right movement in all trial types, with a straightforward relationship to reaction times, and was absent following cues that successfully prompted animals not to move. A movement-linked beta ERD is consistent with many previous studies of human sensorimotor cortex (Jasper and Penfield, 1949), although in our experiments it occurred slightly

later than expected—near completion of the brief movement rather than initiation. The relatively long latency of the beta ERS places further constraints on its potential functional significance. As it typically trans-isomer solubility dmso occurred at, or just after, the fastest reaction times, the beta ERS does not appear to be a necessary link in a serial chain of subprocesses using sensory input to select and initiate motor output (Meyer et al., 1988). Similarly, it is unlikely that the beta ERS is causally involved in cue-evoked cancellation of movements, as in our Stop-signal task the second beta peak occurred substantially after the “stop-signal reaction time” (SSRT, Table S1 and Figure 4D), an inferred measure of the speed of action cancellation (Logan et al., 1984). Despite this relatively slow pace of cue-evoked beta power change, there was a clear relationship between the

presence of beta oscillations and ongoing behavior, with higher beta power Rutecarpine preceding more slowly initiated movements (see also Chen et al., 2007 and Pogosyan et al., 2009). Our present data are consistent with observations that cortical-BG circuits show both spontaneous and regulated transitions between discrete dynamic states (Berke, 2009), at least one of which is characterized by high beta power. We suggest that beta represents a relatively “stabilized” state during which a change in behavioral program is less likely. As brain circuits establish behavioral plans, entry into the stabilized state would serve the adaptive function of reducing interference from other salient cues and competing alternative actions. Conversely, premature or unregulated entry into beta at critical moments would tend to retard the preparation of intended actions, contributing to both natural reaction time variation in normal subjects, and movement difficulties in PD. This view of beta oscillations builds upon extensive prior findings and theoretical discussion.