Positive surgical margins after completion of surgical treatment and advanced neck disease were shown to be significant negative prognostic factors. The occult metastasis rate was 18.4%.
Conclusion:
Primary surgical treatment is a very effective modality against locally limited tonsillar carcinoma. Low rates of complications and permanent tracheotomies are to be expected. (C) 2011 Elsevier Ltd. All rights reserved.”
“Objective: Low vitamin D (25 OH vitamin D) is implicated in the development of diabetes and the metabolic syndrome. We examined whether hypovitaminosis D has a clinically significant impact on glycaemia, metabolic status and inflammatory markers in Chinese patients with established type 2 diabetes.
Methods: Characteristics of 109 patients aged over 50 years were stratified by 25 OH vitamin D status. Patients identified as 25 OH vitamin D deficient (<= 50 nmol/L) received cholecalciferol 2,000 IU daily for three MAPK inhibitor months. Measurement of HbA1c, metabolic syndrome parameters, 25 OH vitamin D, calcium, phosphate, PTH, hsCRP and ferritin were taken at baseline and then 25 OH vitamin D, PTH, calcium, phosphate monthly for three months in those on replacement therapy.
Results:
Vitamin D deficiency was common, affecting 36% of patients. There was no impact of hypovitaminosis D on metabolic syndrome status, HbA1c or insulin use (p >= 0.4 for all) and no association between 250HVitD and ferritin or hsCRP (p >= 0.3 for all). Neither BMI nor the metabolic syndrome affected the incremental rise in 250HVitD 17DMAG Cytoskeletal Signaling inhibitor levels during supplementation.
Conclusion: There is no relationship between hypovitaminosis D and metabolic control or inflammatory
markers in established type 2 diabetes. This suggests that at least in Chinese populations, the effect of low vitamin D is not clinically significant once diabetes is established. Future 250HVitD intervention trials should therefore focus on prevention in pre-diabetes.”
“Purpose: To investigate the impact of prophylactic extended lymphadenectomy on survival for patients with node-negative (pN0) advanced gastric cancer according to the extent of lymph node dissection.
Methods: EPZ5676 This study retrospectively investigated the clinicopathological characteristics and prognostic outcomes of 458 patients who had pN0 advanced gastric cancer between 1995 and 2001. Postoperative survival was compared in patients who underwent different extents of prophylactic lymphadenectomy.
Results: The overall 5-year and 10-year survival rates were 62.01% (284/458) and 40.83% (187/458), respectively. The survival rates differed significantly in patients who underwent a different extent of prophylactic lymphadenectomy (<= D1+ versus D2 versus D3 versus >= D3) (X-2 = 8.59, P=0.035). Survival in patients who received less than D1+ dissection, however, were not significantly better than patients who received D2 dissection (X-2 = 0.907, P = 0.341).