Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.”
“This study investigated 6-year follow-up mortality rates and cause of death for persons younger than 45 years old with a history of hospitalisation for major psychiatric disorders

after the introduction of the National Health Insurance (NHI). Linkage data combining death certificates with Taiwan NHI research claims data were used. The study cohort was comprised all patients under the age of C646 research buy 45 years, who had been hospitalised for major psychiatric disorders in 1998. Patients aged <45 years undergoing an appendectomy were selected as a control group. Cox proportional hazard regressions were performed to compute the adjusted 6-year hazard ratios. For patients with

schizophrenia, major depression, or bipolar disorder, the adjusted risks of dying during the follow-up period were significantly 4.614, 3.707 and 3.866, respectively, times higher than that for appendectomy patients. The adjusted hazard ratios of non-natural dying during the follow-up period were significantly 16.316, 14.626 and 8.481 times for female patients with schizophrenia, Thiazovivin cell line major depression, and bipolar disorder, respectively, as high as for female appendectomy patients. The continuing excess mortality among psychiatric patients, from both natural and unnatural causes, still remains even after implementation of a NHI. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“It is by now well known that,

at the molecular Adenosine triphosphate level, the core of the circadian clock of most living species is a negative feedback loop where some proteins inhibit their own transcription. However, it has recently been shown that post-translational processes, such as phosphorylations, are essential for a correct timing of the clock. Depending on which sites of a circadian protein are phosphorylated, different properties such as degradation, nuclear localization and repressing power can be altered. Furthermore, phosphorylation domains can be related in a positive way, giving rise to consecutive phosphorylations, or in a negative way, hindering phosphorylation at other domains. Here we present a simple mathematical model of a circadian protein having two mutually exclusive domains of phospholylation. We show that the system has limit cycles that arise from a unique fixed point through a Hopf bifurcation. We find a set of parameters, with realistic values, for which the limit cycle has the same period as the wild type circadian oscillations of the fruit fly. The domains act as a switch, in the sense that alterations in their phosphorylation can alter the period of circadian oscillation in opposite ways, increasing or decreasing the period of the wild type oscillations.